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Posts Tagged ‘GlaxoSmithKline’

Drug Companies Paid Doctors To Prescribe Lists

In Health on May 8, 2013 at 17:03

It is known hat Doctors resort to unethical practices.

I have posted how a Doctor forced a patient to undergo operations to complete the target and the patient turning up Dead!

Under Health, I have also listed various unethical practices by the Doctors , Hospitals.

ProPublica is an independent, non-profit newsroom that produces investigative journalism in the public interest. Our work focuses exclusively on truly important stories, stories with “moral force.” We do this by producing journalism that shines a light on exploitation of the weak by the strong and on the failures of those with power to vindicate the trust placed in them.

Following is an excerpt from their investigations.

The next time your doctor prescribes a medicine, recall this and check if the medicine is really needed and will help you.

Money paid by Drug Companies to Doctors.

Drug Companies Paid Doctors.

“When Dollars for Docs first launched in 2010, ProPublica spoke with several of the dozens of doctors who had earned more than $200,000 from their speaking and consulting work for drug companies. Now, with records from more companies and more years of data, we’ve identified 22 doctors who’ve earned at least $500,000 since 2009 — including one, Jon Draud, who was paid more than $1 million.”

The totals listed here cover different time periods and spending categeories, and aren’t directly comparable. See notes below. See what each company discloses »

Company Total Disclosed
AbbVie
Disclosed: July to Sept. 2012
$6.9M
Allergan
Disclosed: July 2011 to Sept. 2012
Ranges*
AstraZeneca
Disclosed: Jan. 2010 to Sept. 2012
$236.1M
Cephalon
Disclosed: Jan. 2009 to Dec. 2012
$89.7M
Eli Lilly
Disclosed: Jan. 2009 to June 2012
$490.6M
EMD Serono
Disclosed: Jan. 2011 to Sept. 2012
$4M
Forest
Disclosed: Jan. to Sept. 2012
$60.8M
GlaxoSmithKline
Disclosed: April 2009 to Sept. 2012
$238.6M
Johnson & Johnson
Disclosed: Jan. 2010 to Sept. 2012
$54.6M
Merck
Disclosed: July 2009 to Sept. 2012
$224.3M
Novartis
Disclosed: Oct. 2010 to Sept. 2012
$54.2M
Pfizer
Disclosed: July 2009 to Sept. 2012
$538.2M
UCB
Disclosed: Jan. to Sept., 2012
$7.2M

Source:

http://projects.propublica.org/docdollars/

Largest Criminal Fines Assessed on Companies In US.

In Business, consumer forum, US on November 24, 2012 at 13:14

BP has  agreed to pay $4.5 billion in a settlement with the federal government over the April 2010 explosion of the drilling rig Deepwater Horizon. The agreement includes nearly $1.3 billion in criminal fines, with the rest of the money going to several government-related entities. The criminal fine is the largest in U.S. history and eclipses a 2009 fine against drug-maker Pfizer Inc.

BP Logo_/bp-4.jpg

BP Logo.

 

1. Following is the List of Heavy Fines imposed by The Justice Department, US.

$1.256 billion in criminal fines, November 2012, against BP PLC for various charges related to the 2010 explosion of the Deepwater Horizon and the resulting oil spill. An estimated 172 million gallons of crude spilled into the Gulf, fouling marshes and beaches, killing wildlife and closing vast areas to fishing. Eleven workers died in the blast. The spill was the nation’s worst offshore oil disaster.

2. $1.195 billion, October 2009, against Pfizer Inc. as part of a settlement of criminal and civil allegations that it promoted the anti-inflammatory drug Bextra for uses and dosages the Food and Drug Administration had rejected because of safety concerns.

3. $956.8 million, plus $43.2 million in forfeitures, October 2010, as part of a GlaxoSmithKline PLC settlement for misbranding the drugs Paxil and Wellbutrin and for failing to report post-approval studies of the drug Avandia to the Food and Drug Administration.

4. $700 million, May 2012, against Abbott Laboratories Inc. as part of a settlement for unlawful promotion of the prescription drug Depakote.

5. $515 million fine and $100 million forfeiture, January 2009, against Eli Lilly and Co. as part of a settlement for off-label marketing of antipsychotics.
 http://www.seattlepi.com/news/science/article/Largest-criminal-fines-against-companies-in-the-US-4041813.php#ixzz2CMzAj6UV

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Clinical Testing of Drugs and Pharma Companies, Patents.

In Business, consumer forum, Medicine, US on March 7, 2012 at 21:50

English: Logo of the .

Image via Wikipedia

Recently I came across an article in The Scientist on the Clinical trials of drugs in the US by the Pharma Corporations.

baby.

MATT COLLINS (BABY); US GOVERNMENT ACCOUNTABILITY OFFICE REPORT, “PEDIATRIC RESEARCH,” MAY 2011

Drugs ,it is reported that , are not tested on children and are marketed.

The FDA is of the opinion that Clinical Trials of Drugs conducted on Children give off reliable results,especially the contra-indications.

I am reproducing a real instance quoted in The Scientist.

But the story of Paxil also illustrates the power of somewhat obscure laws that have saved children’s lives by changing the way drugmakers test their products.

Paxil—which increases extracellular levels of the neurotransmitter serotonin by inhibiting its reuptake into presynaptic cells—was approved by the US Food and Drug Administration in 1992, and by 2000 it was making the drug company GlaxoSmithKline (GSK) $2 billion per year. But around this time, problems with Paxil began to surface. Adult and adolescent patients were anecdotally reporting side effects, including sexual dysfunction, weight gain, high blood pressure, and increased suicidality—an uptick in thoughts of suicide or self-inflicted injury in some severely depressed patients. These reports of increased suicidality particularly worried pediatricians.

In 1999 the FDA sent GSK a letter requesting that the company conduct clinical trials of Paxil in children and adolescents. To sweeten the deal, the FDA offered GSK a 6-month marketing exclusivity extension for Paxil in return. This extension, which in effect would buy GSK 6 extra months of patent protection by delaying marketing of generic versions, was an incentive written into the FDA Modernization Act (FDAMA) of 1997.

GSK eventually agreed to conduct the requested studies and submitted the results to the FDA sometime in early 2002, after FDAMA had expired and been replaced by the Best Pharmaceuticals for Children Act (BPCA) of 2002. Though GSK’s own reports on preliminary studies of Paxil in adolescents indicated that it was safe and more effective than a placebo—a heavily disputed interpretation contained in the article reporting the results of the now infamous study 3291—the FDA’s analyses of Paxil studies found that suicidal thoughts, suicide attempts, and episodes of self-harm were almost twice as high in young patients with major depressive disorder taking the drug than among those taking a placebo. To boot, the agency found that the drug was no more effective than placebo in treating major depression in children and adolescents”

The point to be noted is that the Company doctored the report.

Imagine a Corporation earning Billions of Dollars, despite getting a undeserved

6 months  of patent protection, the company thought it fit to doctor the

report,with scant report for Human Life.

The Companies dodge testing on Children because of Legal implications and high cost of testing on children.

Another point I note is that is testing drugs on Children Safe for them?

I also read an interesting comment  on Patents.

Featured Comment

Legislators should remember who pays their salaries and to whom they are responsible. If taxpayers fund any part of a research activity then (a) no patents or copyrights should issue as a result, and (b) all results and unprocessed data should be available freely, similarly funded by the taxpayers. If the researchers and their sponsoring organizations don’t like the bargain, they should seek funding from non-public sources.tddial, Elsevier Abandons Anti-Open Access Bill

VERY THOUGHTFUL AND VALID.

http://the-scientist.com/2012/03/01/are-the-kids-alright/#fn-21915-1

Parkinson’s cure Medicines makes one Psychotic/Gay Sex Addict.

In Health on February 2, 2011 at 11:26

Illustration of Parkinson's disease

Image via Wikipedia

Parkinson’s is one of the diseases for which Science has no real answer.

There is no case where such disease has been cured as in cancer.

As of now medicines that are available do not cure but definitely have serious side effects as in this case.

Pharma companies do not reveal details of Clinical trials where side effects are indicated.( please read my Blogs under Health).

Best preventive measures Healthy Food, adequate rest, least consumption of tobacco/liquor and avoidance of the habit of popping pills for slightest health problems.

Story:

A MARRIED dad is suing the makers of a drug he took for Parkinson’s disease, claiming it turned him into a psychotic gay sex addict.

Didier Jambart, 51, says the drastic side-effects also saw him start cross-dressing and get hooked on internet gambling.

He is demanding £400,000 damages from pharmaceutical giant GlaxoSmithKline, the makers of Requip, and his consultant.

Revealing his torment, the ex-bank worker and town councillor blames the drug for his three suicide attempts.

Soon after being prescribed the pills in 2003 his behaviour changed. But he said: “Then my neurologist increased the dose and I completely lost the plot. I stole bank cards from friends and used them to gamble. I also sold my children’s toys and I borrowed money. In total I lost between £60,000 to £90,000 online.”

Read more: http://www.mirror.co.uk/news/top-stories/2011/02/02/married-man-sues-pharmaceutical-giant-over-claims-parkinson-s-disease-treatment-tablet-turned-him-into-a-psychotic-gay-sex-addict-115875-22892203/#ixzz1CmIAWIFa
Related:

Parkinson’s..

Symptoms

The disorder may affect one or both sides of the body. How much function is lost can vary.

Symptoms may be mild at first. For instance, the patient may have a mild tremor or a slight feeling that one leg or foot is stiff and dragging.

Symptoms include:

  • Movement problems
    • Difficulty starting or continuing movement, such as starting to walk or getting out of a chair
    • Loss of small or fine hand movements; writing may become small and difficult to read; eating becomes difficult
    • Slowed movements
    • Stooped position

     

  • Rigid or stiff muscles, often beginning in the legs
  • Shaking, tremors
    • Tremors usually occur in the limbs at rest, or when the arm or leg is held out
    • Tremors go away during movement
    • Over time, tremor can be seen in the head, lips, tongue, and feet
    • May be worse when tired, excited, or stressed
    • Finger-thumb rubbing (pill-rolling tremor) may be present

     

  • Slowed, quieter speech and monotone voice

Other symptoms:

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001762

Genes play a bigger role in Parkinson’s disease than previously thought, according to the largest genetic study yet.

http://www.bbc.co.uk/news/health-12338325

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